HeCaToS
The HeCaToS project (Hepatic and Cardiac Toxicity Systems modelling) aims at developing integrative in silico
tools for predicting human liver and heart toxicity. The objective is
to develop an integrated modeling framework, by combining advances in
computational chemistry and systems toxicology, for modelling toxic
perturbations in liver and heart across multiple scales.
This framework will include vertical
integrations of representations from drug(metabolite)-target
interactions, through macromolecules/proteins, to (sub-)cellular
functionalities and organ physiologies, and even the human whole-body
level.
www.hecatos.eu
EXPOSOMICS
The
exposome concept refers to the totality of environmental exposures from
conception onwards, and is a novel approach to studying the role of the
environment in human disease. The EXPOsOMICS project aims to
develop a new approach to assess environmental exposures, primarily
focusing on air pollution and water contaminants. Using ‘omic’ techniques
the collected exposure data can be linked to biochemical and molecular
changes in our body. The results will help to improve our understanding
on how these pollutants influence the risk of developing chronic
diseases.
www.exposomicsproject.eu
EuRhythDia
The objective of the project is to achieve breakthroughs in the understanding of the
causality between inner clock rhythm disturbances and the development
of type 2 diabetes/obesity, and to verify whether re-setting the
circadian clock through lifestyle interventions (exercise, diet, light
exposure and melatonin intake) alters cardiometabolic risk to a
clinically relevant degree.
www.eurhythdia.eu
EPI-FEM-CARE
EPIGENETICS FOR FEMALE PERSONALIZED CANCER CARE
EpiFemCare aims to uncover new methods for screening, diagnosing and
personalising treatment of breast and ovarian cancers. The project will
use cutting edge technologies from the field of epigenetics to develop
blood tests.
www.epifemcare.eu
diXa
The main objective of the "Data Infrastructure for Chemical Safety"
(diXa) project is to further develop and adopt a robust and sustainable
service infrastructure (e.g. data infrastructure and e-science
environment) for harboring multiplexed data sets as produced by past,
current and future EU research projects on developing non-animal tests
for predicting chemical safety, in linkage with other globally
available chemical/toxicological data bases and data bases on molecular
data of human disease.
www.dixa-fp7.eu
CarcinoGENOMICS
Development of a high throughput
genomics-based test for assessing genotoxic and carcinogenic properties
of chemical compounds in vitro as an alternative to current rodent
bioassays for genotoxicity and carcinogenicity.
www.carcinogenomics.eu
Innomed
Assess the value of combining
results from ‘omics technologies together with the results from
more conventional toxicology methods in more informed decision making
in preclinical safety evaluation.